STECEF-S 375
Composition
Ceftriaxone 250mg + Sulbactam 125mg Injection
Indication
Ceftriaxone + Sulbactam is a combination medication widely used in the treatment of various bacterial infections. Ceftriaxone, a third-generation cephalosporin antibiotic, is effective against a broad spectrum of bacteria. Its primary mechanism of action involves inhibiting the synthesis of the bacterial cell wall. By binding to penicillin-binding proteins (PBPs), ceftriaxone disrupts the construction of the peptidoglycan layer, an essential component of the bacterial protective covering. This inhibition results in the weakening and eventual rupture of the bacterial cell wall, leading to the death of the bacteria.
However, some bacteria produce enzymes called beta-lactamases that can break down antibiotics like ceftriaxone, rendering them ineffective. This is where sulbactam plays a crucial role. Sulbactam is a beta-lactamase inhibitor that binds to and inactivates these enzymes, thereby preventing the degradation of ceftriaxone. By inhibiting beta-lactamases, sulbactam enhances the efficacy of ceftriaxone, allowing it to combat beta-lactamase- producing bacteria more effectively.
The combination of ceftriaxone 250mg + sulbactam 125mg, known as Stecef S 375 broadens the antibiotic spectrum and boosts the overall effectiveness against resistant bacterial strains. This makes it particularly useful in treating a variety of infections, including those of the respiratory tract, urinary tract, skin and soft tissues, and intra-abdominal infections. The synergistic action of ceftriaxone and sulbactam ensures a more comprehensive approach to bacterial eradication, especially in environments where antibiotic resistance is a significant concern.
In clinical practice, the combination of ceftriaxone 250mg and sulbactam 125mg injection is recognized for its strong antibacterial activity and effectiveness against resistant strains. This formulation serves as a valuable treatment option within the antimicrobial spectrum, offering dependable results for patients with bacterial infections. Stecef S 375 is designed to meet a wide range of clinical needs, ensuring consistent quality and therapeutic performance.
Contraindication
Increased white blood cell count (eosinophils), decreased white blood cell count (lymphocytes), Low blood platelets, Rash, Diarrhoea, Increased liver enzymes, Injection site reactions (pain, swelling, redness).
Storage
Cool & Dry Place
Dosage
As directed by a Medical Practitioner or Physician.
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